Sally N Adebamowo, Donna Spiegelman, Walter C Willett, Kathryn Yards Rexrode, Association anywhere between intakes from magnesium, potassium, and you can calcium and you will danger of heart attack: 2 cohorts folks lady and updated meta-analyses, The American Record out of Scientific Diet, Regularity 101, Topic six, , Profiles 1269–1277,
Conceptual
Background: Possible investigation to the family members regarding magnesium, potassium, and you will calcium supplements intakes that have coronary attack risk is contradictory, and our very own training, the outcome out of a mixed nutrient diet plan get hasn’t been looked at.
Objective: We checked connections ranging from consumption off magnesium, potassium, and calcium and you will threat of experience coronary arrest inside the 86,149 feamales in the newest Nurses’ Wellness Data (NHS) I and you may 94,715 ladies in this new NHS II.
Design: Within prospective cohort study, i calculated Several hours out of coronary attack from the quintiles from intake for every mineral as well as for a blended diet plan score of all step three minerals by using multivariate Cox proportional possibility models. Likewise, i updated meta-analyses to the slimming down consumption ones nutrition and you can chance of heart attack.
Results: Through the follow-upwards (31 y on NHS I; 22 y about NHS II) all in all, 3780 incident stroke cases was indeed reported. Pooled multivariate RRs off total coronary attack for ladies in the large compared with a reduced quintiles was 0.87 (95% CI: 0.78, 0.97) to possess total magnesium, 0.89 (95% CI: 0.80, 0.99) getting overall potassium, and you can 0.97 https://datingranking.net/sapiosexual-dating (95% CI: 0.87, step 1.09) having complete calcium intake. Pooled RRs for women about higher compared to the lowest quintiles out-of a blended nutrient eating plan get were 0.72 (95% CI: 0.65, 0.81) to own overall heart attack, 0.78 (95% CI: 0.66, 0.92) to own ischemic heart attack, and you will 0.80 (95% CI: 0.61, 1.04) having hemorrhagic heart attack. In the updated meta-analyses of all prospective education up to now, new combined RR off complete heart attack is actually 0.87 (95% CI: 0.83, 0.92) for an one hundred-mg/d escalation in magnesium consumption, 0.91 (95% CI: 0.88, 0.94) to possess a a thousand-mg/d escalation in potassium consumption, and you may 0.98 (95% CI: 0.94, step 1.02) to have a three hundred-mg/d upsurge in calcium supplements consumption.
Conclusions: A combined nutrient eating plan get is inversely of the danger of heart attack. Higher intakes off magnesium and potassium but not calcium supplements were including notably with the smaller risk of stroke in females.
Introduction
Magnesium is a vital nutrient and you can cofactor to possess >300 enzymatic responses within the body ( 1). Magnesium is the second most-numerous intracellular cation close to potassium ( 2). Calcium supplements is the most-plentiful mineral in the body. Such as magnesium and you will potassium, calcium is vitally involved in cardio properties ( 3). Large weight-loss consumption of each and every ones minerals have been reported so you can all the way down likelihood of blood pressure ( 4– 7), the principal convertible coronary arrest chance grounds. not, only a few potential training tested the brand new loved ones anywhere between weight loss and extra consumption of them vitamins and you will danger of coronary arrest in women, and results have been inconsistent. Possible degree into the Europe exhibited magnesium intake, yet not intake out of potassium or calcium supplements, is actually notably associated with the less risk of coronary arrest ( 7, 8). In america, intakes off potassium and you may magnesium, but not away from calcium supplements, have been from the smaller coronary arrest risk within the boys ( 9), whereas calcium supplements and potassium intakes, however magnesium intake, was basically from the faster coronary arrest exposure in females ( 10). And, that data displayed no complete organization between any of these nutritional elements and you may chance of coronary attack ( 11).
The possible observational studies which were held did not include follow-up past 15 y along with a comparatively few event coronary arrest events, plus in most studies, new separate effect of each nutrient consumption regarding pills and coronary attack items wasn’t checked out. In this post, you can expect proof with the connection of each and every nutrient intake out-of dieting and capsules having likelihood of full, ischemic, and hemorrhagic event strokes. On the other hand, i hypothesized you to definitely a blended diet get of all the 3 nutrition are associated with the smaller coronary arrest risk mainly because nutrients exists together with her in meals, and you will intakes are strongly synchronised. We treated these types of seeks from inside the You women that was basically used prospectively on the 2 highest cohorts the fresh Nurses’ Fitness Data (NHS) 5 I and II.